Lipid Metabolism
how many ATP come out of lipid metabolism and what are the steps in the simplest terms please.?
please. Simnple terms..I don’t need to get in the meat of it. Just the breakdown of the fatty acid, what happens inglycolosis, Krebs and Electron Transoprt Cycle.
The majority of fatty acids are metabolized using beta-oxidation. Essentially, a series of four enzymes oxidize the beta-carbon, shorting the fatty acid chain by two carbons. The electrons lost are transferred to electron carriers, and a molecule of acetyl-CoA is produced.
One round of beta-oxidation produces 1 QH2, 1 NADH, and 1 acetyl-CoA molecule. The citric acid cycle is used to convert the molecule of acetyl-CoA into 3 NADH, 1 QH2, and 1 GTP. Through oxidative phosphorylation:
2 QH2 –> 4 ATP (2 per QH2)
4 NADH –> 12 ATP (3 per NADH)
1 GTP –> 1 ATP
Each round of beta-oxidation shortens the fatty acid chain by two carbons and produces 17 ATP. Therefore, one molecule of palmitoleic acid, which contains 16 carbons, could undergo beta-oxidation 7 times and produce 131 molecules of ATP!
PS The answer directly below mine is for one molecule of glucose… Not what you want. Lipids don’t go through glycolysis. Acetyl-CoA also cannot enter gluconeogenesis in humans either because we lack the enzyme needed to enter the glyoxylate cycle.
Lipid Metabolism, Part 4 of 8
Metabolism Masterclass